Single-strand Breakage in Mammalian Chromosomal DNA: Sensitive Detection by Application of a Sedimentation Anomaly
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Baicalin promoted the repair of DNA single strand breakage caused by H2O2 in cultured NIH3T3 fibroblasts.
The protective effect of Baicalin, a flavonoid isolated from the root of Scutellaria baicalensis G., on H2O2-induced DNA single strand break (SSB) was examined in NIH3T3 mouse fibroblasts by Comet assay (single cell gel electrophoresis technique). When the cells were pulse-chased with H2O2 (0.1-0.5 mM) for 15 min in fetal bovine serum (FBS)-free Dulbecco's Modified Eagle's Medium (DMEM), SSB oc...
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ژورنال
عنوان ژورنال: International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine
سال: 1980
ISSN: 0020-7616
DOI: 10.1080/09553008014550711